Nivel de desarrollo de práctcas de RSE en 123 bodegas de Gran Mendoza, Valle de Uco, San Rafael y General Alvear : (2009-2015)

El presente trabajo se corresponde con una línea de investigación iniciada en el año 2009, de tipo descriptiva y de diagnóstico, en el sector vitivinícola de Mendoza - Argentina en materia de Responsabilidad Social Empresaria (RSE), financiada por la SCTyP de la UNCuyo. La misma se ha dividido en diferentes etapas, a saber: 2009/2011 Región Vitivinícola Gran Mendoza (departamentos Luján de Cuyo, Maipú, Godoy Cruz, Guaymallén y Capital); 2011/2013 Región Vitivinícola Valle de Uco (departamentos San Carlos, Tunuyán y Tupungato); 2013/2015 Región Vitivinícola Sur (departamentos San Rafael y General Alvear).Fil: Roby, Osvaldo. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Sanchez, Esther. Universidad Nacional de Cuyo. Facultad de Ciencias Económica

Turismo sustentable. Un acercamiento a su oferta

Amplios esfuerzos se han llevado a cabo con la finalidad de lograr una actividad turística sustentable; sin embargo, la discusión acerca del concepto, alcances y aplicaciones es una constante en el ámbito académico. El objetivo de este artículo es analizar cómo se ha conceptualizado la sustentabilidad en el ámbito turístico, tomando como referencia los dos modelos de desarrollo predominantes: el de masas y el alternativo. Esto se logra a partir de la revisión bibliográfica acerca de sus postulados teóricos, haciendo énfasis en el análisis de la oferta, sus coincidencias y diferencias. A lo largo del documento se presentan componentes descriptivos, deductivos y explicativos que llevan a la reflexión acerca de la contribución que cada uno de estos modelos tiene para la sustentabilidad de los destinos

Light Generation and Harvesting in a Van der Waals Heterostructure

Two-dimensional (2D) materials are a new type of materials under intense study because of their interesting physical properties and wide range of potential applications from nanoelectronics to sensing and photonics. Monolayers of semiconducting transition metal dichalcogenides MoS2 or WSe2 have been proposed as promising channel materials for field-effect transistors (FETs). Their high mechanical flexibility, stability and quality coupled with potentially inexpensive production methods offer potential advantages compared to organic and crystalline bulk semiconductors. Due to quantum mechanical confinement, the band gap in monolayer MoS2 is direct in nature, leading to a strong interaction with light that can be exploited for building phototransistors and ultrasensitive photodetectors. Here, we report on the realization of light-emitting diodes based on vertical heterojunctions composed of n-type monolayer MoS2 and p-type silicon. Careful interface engineering allows us to realize diodes showing rectification and light emission from the entire surface of the heterojunction. Electroluminescence spectra show clear signs of direct excitons related to the optical transitions between the conduction and valence bands. Our pn diodes can also operate as solar cells, with typical external quantum efficiency exceeding 4%. Our work opens up the way to more sophisticated optoelectronic devices such as lasers and heterostructure solar cells based on hybrids of two-dimensional (2D) semiconductors and silicon.Comment: Submitted versio

Preclinical discovery of duloxetine for the treatment of depression

Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases are associated with poor treatment outcomes. From the emergence of the monoamine hypothesis of depression, the first-line treatment for MDD had mainly acted by inhibiting monoamine reuptake, and thereby increasing these levels in the synaptic cleft. However, in recent years, several newantidepressant drugs have appeared, including duloxetine, a dual serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor recommended for the treatment of MDD. Areas covered: The article reviews and discusses the biochemical and functional profile of duloxetine splitting the review into acute and long-term treatment with this dual monoamine reuptake inhibitor. In addition, the authors summarize available preclinical behavioral research data, which have demonstrated among other effects, the antidepressant-like activity of duloxetine in several animal models. The authors focus on the most recent literature on synaptic neuroplasticity modulation of this antidepressant drug. Finally, the authors briefly mention other approved indications of duloxetine. Expert opinion: Duloxetine inhibits 5-HT and NA reuptake, effectively desensitizes various autoreceptors and promotes neuroplasticity. Clinically, duloxetine is an effective antidepressant that is well tolerated and has significant efficacy in the treatment of MDD. associated with poor treatment outcomes. From the emergence of the monoamine hypothesis of depression, the first-line treatment for MDD had mainly acted by inhibiting monoamine reuptake, and thereby increasing these levels in the synaptic cleft. However, in recent years, several new antidepressant drugs have appeared, including duloxetine, a dual serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor recommended for the treatment of MDD

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently prescribed to treat this pathology. Yet, many patients are refractory to the available therapeutic drugs, which mainly act by increasing the levels of the monoamines serotonin and noradrenaline in the synaptic cleft. Even in the cases antidepressants are effective, it is usually observed a delay of a few weeks between the onset of treatment and remission of the clinical symptoms. Additionally, many of these patients who show remission with antidepressant therapy present a relapse of depression upon treatment cessation. Thus research has focused on other possible molecular targets, besides monoamines, underlying depression. Both basic and clinical evidence indicates that depression is associated with several structural and neurochemical changes where the levels of neurotrophins, particularly of brain-derived neurotrophic factor (BDNF), are altered. Antidepressants, as well as other therapeutic strategies, seem to restore these levels. Neuronal atrophy, mostly detected in limbic structures that regulate mood and cognition, like the hippocampus, is observed in depressed patients and in animal behavioural paradigms for depression. Moreover, chronic antidepressant treatment enhances adult hippocampal neurogenesis, supporting the notion that this event underlies antidepressants effects. Here we review some of the preclinical and clinical studies, aimed at disclosing the role of neurotrophins in the pathophysiological mechanisms of depression and the mode of action of antidepressants, which favour the neurotrophic/neurogenic hypothesis

Origen, concepción y tratamiento del ciclo de vida de los destinos turísticos: una reflexión entorno al modelo de butler

Desde su surgimiento, el Modelo del Ciclo de Vida de los Destinos Turísticos (MCVDT) desarrollado en el año 1980 por Richard Butler, dio lugar a grandes discusiones y generó una vasta literatura enfocada a su aplicación. Extenso ha sido el escrutinio del cual ha sido objeto, y amplias sus adaptaciones. En este trabajo, a través de una revisión bibliográfica, se busca establecer su origen, concepción y tratamiento, que ha llevado a lo largo de más de tres décadas, con la finalidad de determinar su vigencia como modelo estratégico de gestión y planeación dentro del ámbito del turismo así como sus limitantes conceptuales.UAEME

The Senegalese Sole Mx gene promoter contains a variable microsatellite region involved in the transcriptional

Interferons (IFNs) play a key role against viral infections by stimulating the expression of IFN stimulated genes, such as Mx. The transcriptional regulation of these genes in fish are poorly understood. The sequencing of the Senegalese sole (Solea senegalensis) Mx gene promoter revealed the presence of a guanosine-citosine rich region that contains a microsatellite, sited close to the translation start codon. The aim of the current study has been to determine the functional role of this region and to study its variability.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Strain Echocardiography to Predict Postoperative Atrial Fibrillation

Postoperative atrial fibrillation (POAF) complicates 15% to 40% of cardiovascular surgeries. Its incidence progressively increases with aging, reaching 50% in octogenarians. This arrhythmia is usually transient but it increases the risk of embolic stroke, prolonged hospital stay, and cardiovascular mortality. Though many pathophysiological mechanisms are known, POAF prediction is still a hot topic of discussion. Doppler echocardiogram and, lately, strain echocardiography have shown significant capacity to predict POAF. Alterations in oxidative stress, calcium handling, mitochondrial dysfunction, inflammation, fibrosis, and tissue aging are among the mechanisms that predispose patients to the perfect "atrial storm". Manifestations of these mechanisms have been related to enlarged atria and impaired function, which can be detected prior to surgery. Specific alterations in the atrial reservoir and pump function, as well as atrial dyssynchrony determined by echocardiographic atrial strain, can predict POAF and help to shed light on which patients could benefit from preventive therapy

Enzymatic hydrolysis of the organic fraction of municipal solid waste : Optimization and valorization of the solid fraction for Bacillus thuringiensis biopesticide production through solid-state fermentation

Altres ajuts: Acord transformatiu CRUE-CSICAltres ajuts: Generalitat de Catalunya pre-doctoral grant (DI 7, 2019)To reach a more sustainable society, the implementation of a circular economy perspective in municipal waste management becomes essential. In this work, the enzymatic hydrolysis of source-separated organic fraction of municipal solid waste (OFMSW) has been optimized as a sugar-releasing step. A liquid sugar concentrate, with a maximum reducing sugar concentration of 50.56 g L, and a solid hydrolyzed fraction were obtained. The effect of the harshness of the hydrolysis conditions was evaluated on the performance of the resulting solid fraction as a substrate for Bacillus thuringiensis biopesticide production through solid-state fermentation. A production of 3.9 × 10 viable cells g dry matter with a 33% sporulation ratio was achieved for milder hydrolysis conditions, highlighting the potential of the solid fraction of hydrolysis as a substrate of SSF processes. The proposed valorization pathway for the OFMSW results in a sugar concentrate with potential for fermentative processes and a fermented solid containing biopesticides from Bacillus thuringiensis